乔伊（简·亚当斯饰）、海伦（劳拉·弗林·博伊尔饰）和特蕾西（辛西娅·史蒂文森饰）是情同手足的三姐妹。他们从小一起长大，度过了一个无忧无虑的童年。长大后，三姐妹踏入了复杂混乱的社会，也遇到了每个女人都无法逃避的情感问题。乔伊和她男友的关系一直问题不断。特蕾西嫁给了一位精神病医生比尔（迪伦·贝克饰），他外表看似光鲜，却隐藏着肮脏丑陋的秘密。艾伦（菲利普·塞默·霍夫曼饰）是比尔的病人。一次偶然的机会，他遇到了迷人的海伦，并爱上了她。与此同时，三姐妹的父母突然宣布结束40年的婚姻。

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